Loss of Bard1, the Heterodimeric Partner of the Brca1 Tumor Suppressor, Results in Early Embryonic Lethality and Chromosomal Instability

The BRCA1 tumor suppressor has been implicated in many cellular pathways, but the mechanisms by which it suppresses tumor formation are not fully understood. In vivo BRCA1 forms a heterodimeric complex with the related BARD1 protein, and its enzymatic activity as a ubiquitin ligase is largely depend...

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Detalhes bibliográficos
Main Authors: McCarthy, Ellen E., Celebi, Julide T., Baer, Richard, Ludwig, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC162231/
https://ncbi.nlm.nih.gov/pubmed/12832489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.14.5056-5063.2003
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