Loss of Bard1, the Heterodimeric Partner of the Brca1 Tumor Suppressor, Results in Early Embryonic Lethality and Chromosomal Instability

The BRCA1 tumor suppressor has been implicated in many cellular pathways, but the mechanisms by which it suppresses tumor formation are not fully understood. In vivo BRCA1 forms a heterodimeric complex with the related BARD1 protein, and its enzymatic activity as a ubiquitin ligase is largely depend...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	McCarthy, Ellen E., Celebi, Julide T., Baer, Richard, Ludwig, Thomas
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 2003
Fag:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162231/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12832489/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.14.5056-5063.2003
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