Loss of Bard1, the Heterodimeric Partner of the Brca1 Tumor Suppressor, Results in Early Embryonic Lethality and Chromosomal Instability

The BRCA1 tumor suppressor has been implicated in many cellular pathways, but the mechanisms by which it suppresses tumor formation are not fully understood. In vivo BRCA1 forms a heterodimeric complex with the related BARD1 protein, and its enzymatic activity as a ubiquitin ligase is largely depend...

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הוצא לאור ב:	Mol Cell Biol
Principais autores:	McCarthy, Ellen E., Celebi, Julide T., Baer, Richard, Ludwig, Thomas
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Taylor & Francis 2003
נושאים:	Mammalian Genetic Models with Minimal or Complex Phenotypes
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162231/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12832489/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.14.5056-5063.2003
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