Loss of Bard1, the Heterodimeric Partner of the Brca1 Tumor Suppressor, Results in Early Embryonic Lethality and Chromosomal Instability

The BRCA1 tumor suppressor has been implicated in many cellular pathways, but the mechanisms by which it suppresses tumor formation are not fully understood. In vivo BRCA1 forms a heterodimeric complex with the related BARD1 protein, and its enzymatic activity as a ubiquitin ligase is largely depend...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: McCarthy, Ellen E., Celebi, Julide T., Baer, Richard, Ludwig, Thomas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2003
Pynciau:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC162231/
https://ncbi.nlm.nih.gov/pubmed/12832489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.14.5056-5063.2003
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