Loss of Bard1, the Heterodimeric Partner of the Brca1 Tumor Suppressor, Results in Early Embryonic Lethality and Chromosomal Instability

The BRCA1 tumor suppressor has been implicated in many cellular pathways, but the mechanisms by which it suppresses tumor formation are not fully understood. In vivo BRCA1 forms a heterodimeric complex with the related BARD1 protein, and its enzymatic activity as a ubiquitin ligase is largely depend...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Mol Cell Biol
Autori principali:	McCarthy, Ellen E., Celebi, Julide T., Baer, Richard, Ludwig, Thomas
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2003
Soggetti:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162231/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12832489/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.14.5056-5063.2003
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!