WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer

Abstract Wnt signaling maintains diverse adult stem cell compartments and is implicated in chemotherapy resistance in cancer. PORCN inhibitors that block Wnt secretion have proven effective in Wnt‐addicted preclinical cancer models and are in clinical trials. In a survey for potential combination th...

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Bibliografiske detaljer

Principais autores:	Amanpreet Kaur, Jun Yi Stanley Lim, Sugunavathi Sepramaniam, Siddhi Patnaik, Nathan Harmston, May Ann Lee, Enrico Petretto, David M Virshup, Babita Madan
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer Nature 2021-03-01
Serier:	EMBO Molecular Medicine
Fag:	BRCA1 DNA repair ETC‐1922159 FANCD2 homologous recombination
Online adgang:	https://doi.org/10.15252/emmm.202013349
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