WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer
Abstract Wnt signaling maintains diverse adult stem cell compartments and is implicated in chemotherapy resistance in cancer. PORCN inhibitors that block Wnt secretion have proven effective in Wnt‐addicted preclinical cancer models and are in clinical trials. In a survey for potential combination th...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Nature
2021-03-01
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| coleção: | EMBO Molecular Medicine |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.15252/emmm.202013349 |
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