Deletion of Mouse Rad9 Causes Abnormal Cellular Responses to DNA Damage, Genomic Instability, and Embryonic Lethality

The fission yeast Schizosaccharomyces pombe rad9 gene promotes cell survival through activation of cell cycle checkpoints induced by DNA damage. Mouse embryonic stem cells with a targeted deletion of Mrad9, the mouse ortholog of this gene, were created to evaluate its function in mammals. Mrad9(−/−)...

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Detalhes bibliográficos
Main Authors: Hopkins, Kevin M., Auerbach, Wojtek, Wang, Xiang Yuan, Hande, M. Prakash, Hang, Haiying, Wolgemuth, Debra J., Joyner, Alexandra L., Lieberman, Howard B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC479733/
https://ncbi.nlm.nih.gov/pubmed/15282322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.16.7235-7248.2004
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