Deletion of Mouse Rad9 Causes Abnormal Cellular Responses to DNA Damage, Genomic Instability, and Embryonic Lethality

The fission yeast Schizosaccharomyces pombe rad9 gene promotes cell survival through activation of cell cycle checkpoints induced by DNA damage. Mouse embryonic stem cells with a targeted deletion of Mrad9, the mouse ortholog of this gene, were created to evaluate its function in mammals. Mrad9(−/−)...

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Auteurs principaux: Hopkins, Kevin M., Auerbach, Wojtek, Wang, Xiang Yuan, Hande, M. Prakash, Hang, Haiying, Wolgemuth, Debra J., Joyner, Alexandra L., Lieberman, Howard B.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2004
Sujets:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC479733/
https://ncbi.nlm.nih.gov/pubmed/15282322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.16.7235-7248.2004
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