Early Embryonic Lethality in Mice with Targeted Deletion of the CTP:Phosphocholine Cytidylyltransferase α Gene (Pcyt1a)

CTP:phosphocholine cytidylyltransferase (CCT) catalyzes a rate-controlling step in the biosynthesis of phosphatidylcholine (PtdCho). Multiple CCT isoforms, CCTα, CCTβ2, and CCTβ3, are encoded by two genes, Pcyt1a and Pcyt1b. The importance of CCTα in mice was investigated by deleting exons 5 and 6 i...

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Bibliographic Details
Main Authors: Wang, Limin, Magdaleno, Susan, Tabas, Ira, Jackowski, Suzanne
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069620/
https://ncbi.nlm.nih.gov/pubmed/15798219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.8.3357-3363.2005
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