Early Embryonic Lethality in Mice with Targeted Deletion of the CTP:Phosphocholine Cytidylyltransferase α Gene (Pcyt1a)

CTP:phosphocholine cytidylyltransferase (CCT) catalyzes a rate-controlling step in the biosynthesis of phosphatidylcholine (PtdCho). Multiple CCT isoforms, CCTα, CCTβ2, and CCTβ3, are encoded by two genes, Pcyt1a and Pcyt1b. The importance of CCTα in mice was investigated by deleting exons 5 and 6 i...

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Detaylı Bibliyografya
Asıl Yazarlar: Wang, Limin, Magdaleno, Susan, Tabas, Ira, Jackowski, Suzanne
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2005
Konular:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069620/
https://ncbi.nlm.nih.gov/pubmed/15798219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.8.3357-3363.2005
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