Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice

Bacillus anthracis, the causative agent of anthrax, secretes three polypeptides, which form the bipartite lethal and edema toxins (LT and ET, respectively). The common component in these toxins, protective antigen (PA), is responsible for binding to cellular receptors and translocating the lethal fa...

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Bibliografski detalji
Izdano u:Clin Vaccine Immunol
Glavni autori: Moayeri, Mahtab, Tremblay, Jacqueline M., Debatis, Michelle, Dmitriev, Igor P., Kashentseva, Elena A., Yeh, Anthony J., Cheung, Gordon Y. C., Curiel, David T., Leppla, Stephen, Shoemaker, Charles B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
Teme:
Clinical Immunology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783422/
https://ncbi.nlm.nih.gov/pubmed/26740390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00611-15
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