Prolonged Prophylactic Protection from Botulism with a Single Adenovirus Treatment Promoting Serum Expression of a VHH-Based Antitoxin Protein

Current therapies for most acute toxin exposures are limited to administration of polyclonal antitoxin serum. We have shown that VHH-based neutralizing agents (VNAs) consisting of two or more linked, toxin-neutralizing heavy-chain-only V(H) domains (VHHs), each binding distinct epitopes, can potentl...

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Detalhes bibliográficos
Main Authors: Mukherjee, Jean, Dmitriev, Igor, Debatis, Michelle, Tremblay, Jacqueline M., Beamer, Gillian, Kashentseva, Elena A., Curiel, David T., Shoemaker, Charles B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149568/
https://ncbi.nlm.nih.gov/pubmed/25170904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106422
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