A Single VHH-Based Toxin-Neutralizing Agent and an Effector Antibody Protect Mice against Challenge with Shiga Toxins 1 and 2

Shiga toxin-producing Escherichia coli (STEC) is a major cause of severe food-borne disease worldwide, and two Shiga toxins, Stx1 and Stx2, are primarily responsible for the serious disease consequence, hemolytic-uremic syndrome (HUS). Here we report identification of a panel of heavy-chain-only ant...

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Bibliografiska uppgifter
Huvudupphovsmän: Tremblay, Jacqueline M., Mukherjee, Jean, Leysath, Clinton E., Debatis, Michelle, Ofori, Kwasi, Baldwin, Karen, Boucher, Courtney, Peters, Rachel, Beamer, Gillian, Sheoran, Abhineet, Bedenice, Daniela, Tzipori, Saul, Shoemaker, Charles B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2013
Ämnen:
Microbial Immunity and Vaccines
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837998/
https://ncbi.nlm.nih.gov/pubmed/24082082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01033-13
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