Intracellular Neutralization of Shiga Toxin 2 by an A Subunit-Specific Human Monoclonal Antibody

Infection of children with Shiga toxin (Stx)-producing Escherichia coli (STEC) is the leading cause of hemolytic-uremic syndrome (HUS). Stx2, one of two toxins liberated by the bacteria, is directly linked with HUS. We have previously shown that Stx2-specific human monoclonal antibodies (HuMAbs) pro...

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Hauptverfasser: Krautz-Peterson, Greice, Chapman-Bonofiglio, Susan, Boisvert, Karen, Feng, Hanping, Herman, Ira M., Tzipori, Saul, Sheoran, Abhineet S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346683/
https://ncbi.nlm.nih.gov/pubmed/18285498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01282-07
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