A Tetraspecific VHH-Based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection

Clostridium difficile infection (CDI), a leading cause of nosocomial infection, is a serious disease in North America, Europe, and Asia. CDI varies greatly from asymptomatic carriage to life-threatening diarrhea, toxic megacolon, and toxemia. The incidence of community-acquired infection has increas...

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Detalles Bibliográficos
Publicado en:Clin Vaccine Immunol
Main Authors: Schmidt, Diane J., Beamer, Gillian, Tremblay, Jacqueline M., Steele, Jennifer A., Kim, Hyeun Bum, Wang, Yaunkai, Debatis, Michele, Sun, Xingmin, Kashentseva, Elena A., Dmitriev, Igor P., Curiel, David T., Shoemaker, Charles B., Tzipori, Saul
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2016
Assuntos:
Clinical Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014919/
https://ncbi.nlm.nih.gov/pubmed/27413067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00730-15
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