A Tetraspecific VHH-Based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection

Clostridium difficile infection (CDI), a leading cause of nosocomial infection, is a serious disease in North America, Europe, and Asia. CDI varies greatly from asymptomatic carriage to life-threatening diarrhea, toxic megacolon, and toxemia. The incidence of community-acquired infection has increas...

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Dettagli Bibliografici
Pubblicato in:Clin Vaccine Immunol
Autori principali: Schmidt, Diane J., Beamer, Gillian, Tremblay, Jacqueline M., Steele, Jennifer A., Kim, Hyeun Bum, Wang, Yaunkai, Debatis, Michele, Sun, Xingmin, Kashentseva, Elena A., Dmitriev, Igor P., Curiel, David T., Shoemaker, Charles B., Tzipori, Saul
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Clinical Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014919/
https://ncbi.nlm.nih.gov/pubmed/27413067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00730-15
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