A Tetraspecific VHH-Based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection

Clostridium difficile infection (CDI), a leading cause of nosocomial infection, is a serious disease in North America, Europe, and Asia. CDI varies greatly from asymptomatic carriage to life-threatening diarrhea, toxic megacolon, and toxemia. The incidence of community-acquired infection has increas...

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Bibliografiske detaljer
Udgivet i:Clin Vaccine Immunol
Main Authors: Schmidt, Diane J., Beamer, Gillian, Tremblay, Jacqueline M., Steele, Jennifer A., Kim, Hyeun Bum, Wang, Yaunkai, Debatis, Michele, Sun, Xingmin, Kashentseva, Elena A., Dmitriev, Igor P., Curiel, David T., Shoemaker, Charles B., Tzipori, Saul
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Clinical Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014919/
https://ncbi.nlm.nih.gov/pubmed/27413067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00730-15
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