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MBX-500 Is Effective for Treatment of Clostridium difficile Infection in Gnotobiotic Piglets

The novel antibiotic MBX-500, dosed at 100, 200, or 400 mg/kg twice daily for 7 days, was evaluated for the treatment of Clostridium difficile infection (CDI) in the gnotobiotic pig model. MBX-500 increased survival at all doses and at high doses improved clinical signs and reduced lesion severity,...

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Bibliografische gegevens
Hoofdauteurs: Steele, Jennifer, Zhang, Quanshun, Beamer, Gillian, Butler, Michelle, Bowlin, Terry, Tzipori, Saul
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719748/
https://ncbi.nlm.nih.gov/pubmed/23689716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00304-13
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