A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection

Infection with Bacillus anthracis, the causative agent of anthrax, can lead to persistence of lethal secreted toxins in the bloodstream, even after antibiotic treatment. VHH single-domain antibodies have been demonstrated to neutralize diverse bacterial toxins both in vitro and in vivo, with protein...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Vrentas, Catherine E., Moayeri, Mahtab, Keefer, Andrea B., Greaney, Allison J., Tremblay, Jacqueline, O'Mard, Danielle, Leppla, Stephen H., Shoemaker, Charles B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076830/
https://ncbi.nlm.nih.gov/pubmed/27539858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.749184
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