A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection

Infection with Bacillus anthracis, the causative agent of anthrax, can lead to persistence of lethal secreted toxins in the bloodstream, even after antibiotic treatment. VHH single-domain antibodies have been demonstrated to neutralize diverse bacterial toxins both in vitro and in vivo, with protein...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Vrentas, Catherine E., Moayeri, Mahtab, Keefer, Andrea B., Greaney, Allison J., Tremblay, Jacqueline, O'Mard, Danielle, Leppla, Stephen H., Shoemaker, Charles B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076830/
https://ncbi.nlm.nih.gov/pubmed/27539858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.749184
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