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Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice

Bacillus anthracis, the causative agent of anthrax, secretes three polypeptides, which form the bipartite lethal and edema toxins (LT and ET, respectively). The common component in these toxins, protective antigen (PA), is responsible for binding to cellular receptors and translocating the lethal fa...

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Bibliografiske detaljer
Udgivet i:Clin Vaccine Immunol
Main Authors: Moayeri, Mahtab, Tremblay, Jacqueline M., Debatis, Michelle, Dmitriev, Igor P., Kashentseva, Elena A., Yeh, Anthony J., Cheung, Gordon Y. C., Curiel, David T., Leppla, Stephen, Shoemaker, Charles B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783422/
https://ncbi.nlm.nih.gov/pubmed/26740390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00611-15
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