A Heterodimer of a VHH (Variable Domains of Camelid Heavy Chain-only) Antibody That Inhibits Anthrax Toxin Cell Binding Linked to a VHH Antibody That Blocks Oligomer Formation Is Highly Protective in an Anthrax Spore Challenge Model

Anthrax disease is caused by a toxin consisting of protective antigen (PA), lethal factor, and edema factor. Antibodies against PA have been shown to be protective against the disease. Variable domains of camelid heavy chain-only antibodies (VHHs) with affinity for PA were obtained from immunized al...

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Publicat a:J Biol Chem
Autors principals: Moayeri, Mahtab, Leysath, Clinton E., Tremblay, Jacqueline M., Vrentas, Catherine, Crown, Devorah, Leppla, Stephen H., Shoemaker, Charles B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358291/
https://ncbi.nlm.nih.gov/pubmed/25564615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.627943
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