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Small-Molecule Inhibitors of Lethal Factor Protease Activity Protect against Anthrax Infection

Bacillus anthracis, the causative agent of anthrax, manifests its pathogenesis through the action of two secreted toxins. The bipartite lethal and edema toxins, a combination of lethal factor or edema factor with the protein protective antigen, are important virulence factors for this bacterium. We...

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Detalhes bibliográficos
Main Authors: Moayeri, Mahtab, Crown, Devorah, Jiao, Guan-Sheng, Kim, Seongjin, Johnson, Alan, Leysath, Clinton, Leppla, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754358/
https://ncbi.nlm.nih.gov/pubmed/23774434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00941-13
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