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Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages

Anthrax lethal toxin (LT) is an important virulence factor for Bacillus anthracis. In mice, LT lyses macrophages from certain inbred strains in less than two hours by activating the Nlrp1b inflammasome and caspase-1, while macrophages from other strains remain resistant to the toxin’s effects. We an...

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Detalhes bibliográficos
Main Authors: Newman, Zachary L., Crown, Devorah, Leppla, Stephen H., Moayeri, Mahtab
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925535/
https://ncbi.nlm.nih.gov/pubmed/20638366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.07.039
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