Anthrax Lethal Factor Cleaves Mouse Nlrp1b in Both Toxin-Sensitive and Toxin-Resistant Macrophages

Anthrax lethal factor (LF) is the protease component of anthrax lethal toxin (LT). LT induces pyroptosis in macrophages of certain inbred mouse and rat strains, while macrophages from other inbred strains are resistant to the toxin. In rats, the sensitivity of macrophages to toxin-induced cell death...

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Bibliographic Details
Main Authors: Hellmich, Kristina A., Levinsohn, Jonathan L., Fattah, Rasem, Newman, Zachary L., Maier, Nolan, Sastalla, Inka, Liu, Shihui, Leppla, Stephen H., Moayeri, Mahtab
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495862/
https://ncbi.nlm.nih.gov/pubmed/23152930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049741
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