Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

NOD-like receptor (NLR) proteins (Nlrps) are cytosolic sensors responsible for detection of pathogen and danger-associated molecular patterns through unknown mechanisms. Their activation in response to a wide range of intracellular danger signals leads to formation of the inflammasome, caspase-1 act...

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Main Authors: Levinsohn, Jonathan L., Newman, Zachary L., Hellmich, Kristina A., Fattah, Rasem, Getz, Matthew A., Liu, Shihui, Sastalla, Inka, Leppla, Stephen H., Moayeri, Mahtab
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315489/
https://ncbi.nlm.nih.gov/pubmed/22479187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002638
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