Antidotes to anthrax lethal factor intoxication. Part 2: Structural modifications leading to improved in vivo efficacy

New anthrax lethal factor inhibitors (LFIs) were designed based upon previously identified potent inhibitors 1a and 2. Combining the new core structures with modifications to the C2-side chain yielded analogs with improved efficacy in the rat lethal toxin model. [BMCL ABSTRACT]

Na minha lista:
Detalhes bibliográficos
Main Authors: Kim, Seongjin, Jiao, Guan-Sheng, Moayeri, Mahtab, Crown, Devorah, Cregar-Hernandez, Lynne, McKasson, Linda, Margosiak, Stephen A., Leppla, Stephen H., Johnson, Alan T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059087/
https://ncbi.nlm.nih.gov/pubmed/21334206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.02.010
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados