Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain

Four core structures capable of providing sub-nanomolar inhibitors of anthrax lethal factor (LF) were evaluated by comparing the potential for toxicity, physicochemical properties, in vitro ADME profiles, and relative efficacy in a rat lethal toxin (LT) model of LF intoxication. Poor efficacy in the...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Jiao, Guan-Sheng, Kim, Seongjin, Moayeri, Mahtab, Crown, Devorah, Thai, April, Cregar-Hernandez, Lynne, McKasson, Linda, Sankaran, Banumathi, Lehrer, Axel, Wong, Teri, Johns, Lisa, Margosiak, Stephen A., Leppla, Stephen H., Johnson, Alan T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295836/
https://ncbi.nlm.nih.gov/pubmed/22342144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.01.095
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia