Clonally expanded CD4(+) T cells can produce infectious HIV-1 in vivo

Reservoirs of infectious HIV-1 persist despite years of combination antiretroviral therapy and make curing HIV-1 infections a major challenge. Most of the proviral DNA resides in CD4(+)T cells. Some of these CD4(+)T cells are clonally expanded; most of the proviruses are defective. It is not known i...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Simonetti, Francesco R., Sobolewski, Michele D., Fyne, Elizabeth, Shao, Wei, Spindler, Jonathan, Hattori, Junko, Anderson, Elizabeth M., Watters, Sarah A., Hill, Shawn, Wu, Xiaolin, Wells, David, Su, Li, Luke, Brian T., Halvas, Elias K., Besson, Guillaume, Penrose, Kerri J., Yang, Zhiming, Kwan, Richard W., Van Waes, Carter, Uldrick, Thomas, Citrin, Deborah E., Kovacs, Joseph, Polis, Michael A., Rehm, Catherine A., Gorelick, Robert, Piatak, Michael, Keele, Brandon F., Kearney, Mary F., Coffin, John M., Hughes, Stephen H., Mellors, John W., Maldarelli, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763755/
https://ncbi.nlm.nih.gov/pubmed/26858442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522675113
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