Clonally expanded CD4(+) T cells can produce infectious HIV-1 in vivo

Reservoirs of infectious HIV-1 persist despite years of combination antiretroviral therapy and make curing HIV-1 infections a major challenge. Most of the proviral DNA resides in CD4(+)T cells. Some of these CD4(+)T cells are clonally expanded; most of the proviruses are defective. It is not known i...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Simonetti, Francesco R., Sobolewski, Michele D., Fyne, Elizabeth, Shao, Wei, Spindler, Jonathan, Hattori, Junko, Anderson, Elizabeth M., Watters, Sarah A., Hill, Shawn, Wu, Xiaolin, Wells, David, Su, Li, Luke, Brian T., Halvas, Elias K., Besson, Guillaume, Penrose, Kerri J., Yang, Zhiming, Kwan, Richard W., Van Waes, Carter, Uldrick, Thomas, Citrin, Deborah E., Kovacs, Joseph, Polis, Michael A., Rehm, Catherine A., Gorelick, Robert, Piatak, Michael, Keele, Brandon F., Kearney, Mary F., Coffin, John M., Hughes, Stephen H., Mellors, John W., Maldarelli, Frank
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763755/
https://ncbi.nlm.nih.gov/pubmed/26858442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522675113
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