Ex vivo activation of CD4(+) T-cells from donors on suppressive ART can lead to sustained production of infectious HIV-1 from a subset of infected cells

The fate of HIV-infected cells after reversal of proviral latency is not well characterized. Simonetti, et al. recently showed that CD4(+) T-cells containing intact proviruses can clonally expand in vivo and produce low-level infectious viremia. We hypothesized that reversal of HIV latency by activa...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Bui, John K., Halvas, Elias K., Fyne, Elizabeth, Sobolewski, Michele D., Koontz, Dianna, Shao, Wei, Luke, Brian, Hong, Feiyu F., Kearney, Mary F., Mellors, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338860/
https://ncbi.nlm.nih.gov/pubmed/28225830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006230
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