HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus

BACKGROUND: HIV-1 viremia that is not suppressed by combination antiretroviral therapy (ART) is generally attributed to incomplete medication adherence and/or drug resistance. We evaluated individuals referred by clinicians for nonsuppressible viremia (plasma HIV-1 RNA above 40 copies/mL) despite re...

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Pubblicato in:J Clin Invest
Autori principali: Halvas, Elias K., Joseph, Kevin W., Brandt, Leah D., Guo, Shuang, Sobolewski, Michele D., Jacobs, Jana L., Tumiotto, Camille, Bui, John K., Cyktor, Joshua C., Keele, Brandon F., Morse, Gene D., Bale, Michael J., Shao, Wei, Kearney, Mary F., Coffin, John M., Rausch, Jason W., Wu, Xiaolin, Hughes, Stephen H., Mellors, John W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
Soggetti:
Clinical Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598056/
https://ncbi.nlm.nih.gov/pubmed/33016926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138099
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