Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART

Little is known about the fraction of human immunodeficiency virus type 1 (HIV-1) proviruses that express unspliced viral RNA in vivo or about the levels of HIV RNA expression within single infected cells. We developed a sensitive cell-associated HIV RNA and DNA single-genome sequencing (CARD-SGS) m...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Wiegand, Ann, Spindler, Jonathan, Hong, Feiyu F., Shao, Wei, Cyktor, Joshua C., Cillo, Anthony R., Halvas, Elias K., Coffin, John M., Mellors, John W., Kearney, Mary F.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422779/
https://ncbi.nlm.nih.gov/pubmed/28416661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617961114
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