Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir

The major obstacle to curing HIV infection is the persistence of cells with intact proviruses that can produce replication-competent virus. This HIV reservoir is believed to exist primarily in CD4(+) T-cells and is stable despite years of suppressive antiretroviral therapy. A potential mechanism for...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Bui, John K., Sobolewski, Michele D., Keele, Brandon F., Spindler, Jonathan, Musick, Andrew, Wiegand, Ann, Luke, Brian T., Shao, Wei, Hughes, Stephen H., Coffin, John M., Kearney, Mary F., Mellors, John W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378418/
https://ncbi.nlm.nih.gov/pubmed/28328934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006283
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