Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir

The major obstacle to curing HIV infection is the persistence of cells with intact proviruses that can produce replication-competent virus. This HIV reservoir is believed to exist primarily in CD4(+) T-cells and is stable despite years of suppressive antiretroviral therapy. A potential mechanism for...

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發表在:PLoS Pathog
Main Authors: Bui, John K., Sobolewski, Michele D., Keele, Brandon F., Spindler, Jonathan, Musick, Andrew, Wiegand, Ann, Luke, Brian T., Shao, Wei, Hughes, Stephen H., Coffin, John M., Kearney, Mary F., Mellors, John W.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2017
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378418/
https://ncbi.nlm.nih.gov/pubmed/28328934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006283
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