Clonally expanded CD4(+) T cells can produce infectious HIV-1 in vivo

Reservoirs of infectious HIV-1 persist despite years of combination antiretroviral therapy and make curing HIV-1 infections a major challenge. Most of the proviral DNA resides in CD4(+)T cells. Some of these CD4(+)T cells are clonally expanded; most of the proviruses are defective. It is not known i...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Simonetti, Francesco R., Sobolewski, Michele D., Fyne, Elizabeth, Shao, Wei, Spindler, Jonathan, Hattori, Junko, Anderson, Elizabeth M., Watters, Sarah A., Hill, Shawn, Wu, Xiaolin, Wells, David, Su, Li, Luke, Brian T., Halvas, Elias K., Besson, Guillaume, Penrose, Kerri J., Yang, Zhiming, Kwan, Richard W., Van Waes, Carter, Uldrick, Thomas, Citrin, Deborah E., Kovacs, Joseph, Polis, Michael A., Rehm, Catherine A., Gorelick, Robert, Piatak, Michael, Keele, Brandon F., Kearney, Mary F., Coffin, John M., Hughes, Stephen H., Mellors, John W., Maldarelli, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763755/
https://ncbi.nlm.nih.gov/pubmed/26858442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522675113
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