Neuroprotective role of SIRT1 in mammalian models of Huntington’s disease through activation of multiple SIRT1 targets

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expanded polyglutamine repeat in huntingtin (Htt) protein. Current management strategies temporarily relieve disease symptoms, but fail to affect the underlying disease progression. We previously demonstrated that calorie r...

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Publicado en:Nat Med
Main Authors: Jiang, Mali, Wang, Jiawei, Fu, Jinrong, Du, Lin, Jeong, Hyun-Kyung, West, Tim, Xiang, Lan, Peng, Qi, Hou, Zhipeng, Cai, Huan, Seredenin, Tamara, Arbez, Nicolas, Zhu, Shanshan, Sommers, Katherine, Qian, Jennifer, Zhang, Jiangyang, Mori, Susumu, Yang, X. William, Tamashiro, Kellie L. K., Aja, Susan, Moran, Timothy H., Luthi-Carter, Ruth, Martin, Bronwen, Maudsley, Stuart, Mattson, Mark P., Cichewicz, Robert H., Ross, Christopher A., Holtzman, David M., Krainc, Dimitri, Duan, Wenzhen
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551453/
https://ncbi.nlm.nih.gov/pubmed/22179319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2558
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