Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease

Huntington’s disease (HD) is caused by an expansion of the trinucleotide poly (CAG) tract located in exon 1 of the huntingtin (Htt) gene leading to progressive neurodegeneration in selected brain regions, and associated functional impairments in motor, cognitive, and psychiatric domains. Since the d...

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Vydáno v:PLoS One
Hlavní autoři: Peng, Qi, Wu, Bin, Jiang, Mali, Jin, Jing, Hou, Zhipeng, Zheng, Jennifer, Zhang, Jiangyang, Duan, Wenzhen
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747517/
https://ncbi.nlm.nih.gov/pubmed/26859386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148839
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