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Inhibition of Drp1 hyperactivation reduces neuropathology and behavioral deficits in zQ175 knock-in mouse model of Huntington’s disease

Mitochondrial dysfunction manifests in the pathogenesis of Huntington’s disease (HD), a fatal and inherited neurodegenerative disease. Dynamin-related protein 1 (Drp1) is the primary component of mitochondrial fission and becomes hyperactivated in various models of HD. We previously reported that in...

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Vydáno v:Biochem Biophys Res Commun
Hlavní autoři: Zhao, Yuanyuan, Sun, Xiaoyan, Qi, Xin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299831/
https://ncbi.nlm.nih.gov/pubmed/30449600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.11.031
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