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Inhibition of Drp1 hyperactivation reduces neuropathology and behavioral deficits in zQ175 knock-in mouse model of Huntington’s disease
Mitochondrial dysfunction manifests in the pathogenesis of Huntington’s disease (HD), a fatal and inherited neurodegenerative disease. Dynamin-related protein 1 (Drp1) is the primary component of mitochondrial fission and becomes hyperactivated in various models of HD. We previously reported that in...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6299831/ https://ncbi.nlm.nih.gov/pubmed/30449600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.11.031 |
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