Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease

Huntington disease is a neurodegenerative condition for which there is no cure to date. Activation of AMP-activated protein kinase has previously been shown to be beneficial in in vitro and in vivo models of Huntington’s disease. Moreover, a recent cross-sectional study demonstrated that treatment w...

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Bibliografiske detaljer
Udgivet i:Exp Mol Med
Main Authors: Sanchis, Ana, García-Gimeno, María Adelaida, Cañada-Martínez, Antonio José, Sequedo, María Dolores, Millán, José María, Sanz, Pascual, Vázquez-Manrique, Rafael P.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549163/
https://ncbi.nlm.nih.gov/pubmed/31165723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0264-9
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