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Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease
Huntington's disease (HD) is a fatal neurodegenerative disease characterized by abnormal motor coordination, cognitive decline and psychiatric disorders. This disease is caused by an expanded CAG trinucleotide repeat in the gene encoding the protein huntingtin. Reduced levels of brain-derived n...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3658168/ https://ncbi.nlm.nih.gov/pubmed/23446639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt098 |
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