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Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease

Huntington's disease (HD) is a fatal neurodegenerative disease characterized by abnormal motor coordination, cognitive decline and psychiatric disorders. This disease is caused by an expanded CAG trinucleotide repeat in the gene encoding the protein huntingtin. Reduced levels of brain-derived n...

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Detalhes bibliográficos
Main Authors: Jiang, Mali, Peng, Qi, Liu, Xia, Jin, Jing, Hou, Zhipeng, Zhang, Jiangyang, Mori, Susumu, Ross, Christopher A., Ye, Keqiang, Duan, Wenzhen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658168/
https://ncbi.nlm.nih.gov/pubmed/23446639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt098
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