trans-(−)-ϵ-Viniferin Increases Mitochondrial Sirtuin 3 (SIRT3), Activates AMP-activated Protein Kinase (AMPK), and Protects Cells in Models of Huntington Disease

Huntington disease (HD) is an inherited neurodegenerative disorder caused by an abnormal polyglutamine expansion in the protein Huntingtin (Htt). Currently, no cure is available for HD. The mechanisms by which mutant Htt causes neuronal dysfunction and degeneration remain to be fully elucidated. Nev...

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Detalhes bibliográficos
Main Authors: Fu, Jinrong, Jin, Jing, Cichewicz, Robert H., Hageman, Serena A., Ellis, Trevor K., Xiang, Lan, Peng, Qi, Jiang, Mali, Arbez, Nicolas, Hotaling, Katelyn, Ross, Christopher A., Duan, Wenzhen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397871/
https://ncbi.nlm.nih.gov/pubmed/22648412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.382226
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