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Targeting Sirtuin-1 in Huntington’s disease: Rationale and Current Status
Huntington’s disease (HD) is an autosomal dominant hereditary disease caused by a trinucleotide repeat mutation in the huntingtin gene that results in an increased number of glutamine residues in the N terminus of huntingtin protein. Mutant huntingtin leads to progressive impairment of motor functio...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3660428/ https://ncbi.nlm.nih.gov/pubmed/23549885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40263-013-0055-0 |
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