Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1β axis in mice

The mitochondrial sirtuin 3 (SIRT3) is involved in suppressing the onset of multiple pathologies, including cardiovascular disease, fatty liver, age-related hearing loss, and breast cancer. But a physiological role of SIRT3 in bone metabolism is not known. Here we show that SIRT3 is a key regulatory...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Huh, Jeong-Eun, Shin, Ji Hye, Jang, Eun Sun, Park, So Jeong, Park, Doo Ri, Ko, Ryeojin, Seo, Dong-Hyun, Kim, Han-Sung, Lee, Seoung Hoon, Choi, Yongwon, Kim, Hyun Seok, Lee, Soo Young
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772385/
https://ncbi.nlm.nih.gov/pubmed/26928655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22511
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