Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation

Global deletion of the gene encoding a nuclear histone deacetylase sirtuin 6 (Sirt6) in mice leads to osteopenia with a low bone turnover due to impaired bone formation. But whether Sirt6 regulates osteoclast differentiation is less clear. Here we show that Sirt6 functions as a transcriptional regul...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Park, So Jeong, Huh, Jeong-Eun, Shin, Jihye, Park, Doo Ri, Ko, Ryeojin, Jin, Gyu-Rin, Seo, Dong-Hyun, Kim, Han-Sung, Shin, Hong-In, Oh, Goo Taeg, Kim, Hyun Seok, Lee, Soo Young
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870620/
https://ncbi.nlm.nih.gov/pubmed/27189179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26186
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