Neuroprotective role of SIRT1 in mammalian models of Huntington’s disease through activation of multiple SIRT1 targets

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expanded polyglutamine repeat in huntingtin (Htt) protein. Current management strategies temporarily relieve disease symptoms, but fail to affect the underlying disease progression. We previously demonstrated that calorie r...

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Detaylı Bibliyografya
Yayımlandı:Nat Med
Asıl Yazarlar: Jiang, Mali, Wang, Jiawei, Fu, Jinrong, Du, Lin, Jeong, Hyun-Kyung, West, Tim, Xiang, Lan, Peng, Qi, Hou, Zhipeng, Cai, Huan, Seredenin, Tamara, Arbez, Nicolas, Zhu, Shanshan, Sommers, Katherine, Qian, Jennifer, Zhang, Jiangyang, Mori, Susumu, Yang, X. William, Tamashiro, Kellie L. K., Aja, Susan, Moran, Timothy H., Luthi-Carter, Ruth, Martin, Bronwen, Maudsley, Stuart, Mattson, Mark P., Cichewicz, Robert H., Ross, Christopher A., Holtzman, David M., Krainc, Dimitri, Duan, Wenzhen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551453/
https://ncbi.nlm.nih.gov/pubmed/22179319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2558
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