BMPR2 Preserves Mitochondrial Function and DNA Integrity During Reoxygenation to Promote Endothelial Survival and Reverse Pulmonary Hypertension

Mitochondrial dysfunction, inflammation and mutant bone morphogenetic protein receptor (BMPR)2 are associated with pulmonary arterial hypertension (PAH), an incurable disease characterized by pulmonary arterial (PA) endothelial cell (EC) apoptosis, decreased microvessels and occlusive vascular remod...

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Vydáno v:Cell Metab
Hlavní autoři: Diebold, Isabel, Hennigs, Jan K., Miyagawa, Kazuya, Li, Caiyun G., Nickel, Nils P., Kaschwich, Mark, Cao, Aiqin, Wang, Lingli, Reddy, Sushma, Chen, Pin-I, Nakahira, Kiichi, Alcazar, Miguel A. Alejandre, Hopper, Rachel K., Ji, Lijuan, Feldman, Brian J., Rabinovitch, Marlene
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394191/
https://ncbi.nlm.nih.gov/pubmed/25863249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.03.010
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