In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and its Target Slug

BACKGROUND: We previously reported high-throughput RNA sequencing analyses that identified heightened expression of the chromatin architectural factor High Mobility Group AT-hook 1 (HMGA1) in pulmonary arterial (PA) endothelial cells (ECs) from idiopathic PA hypertension (IPAH) patients compared to...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Hopper, Rachel K., Moonen, Jan-Renier A.J., Diebold, Isabel, Cao, Aiqin, Rhodes, Christopher J., Tojais, Nancy F., Hennigs, Jan K., Gu, Mingxia, Wang, Lingli, Rabinovitch, Marlene
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856565/
https://ncbi.nlm.nih.gov/pubmed/27045138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.115.020617
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