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BMPR2 Preserves Mitochondrial Function and DNA Integrity During Reoxygenation to Promote Endothelial Survival and Reverse Pulmonary Hypertension

Mitochondrial dysfunction, inflammation and mutant bone morphogenetic protein receptor (BMPR)2 are associated with pulmonary arterial hypertension (PAH), an incurable disease characterized by pulmonary arterial (PA) endothelial cell (EC) apoptosis, decreased microvessels and occlusive vascular remod...

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Dades bibliogràfiques
Publicat a:Cell Metab
Autors principals: Diebold, Isabel, Hennigs, Jan K., Miyagawa, Kazuya, Li, Caiyun G., Nickel, Nils P., Kaschwich, Mark, Cao, Aiqin, Wang, Lingli, Reddy, Sushma, Chen, Pin-I, Nakahira, Kiichi, Alcazar, Miguel A. Alejandre, Hopper, Rachel K., Ji, Lijuan, Feldman, Brian J., Rabinovitch, Marlene
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394191/
https://ncbi.nlm.nih.gov/pubmed/25863249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.03.010
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