BMPR2 Preserves Mitochondrial Function and DNA Integrity During Reoxygenation to Promote Endothelial Survival and Reverse Pulmonary Hypertension

Mitochondrial dysfunction, inflammation and mutant bone morphogenetic protein receptor (BMPR)2 are associated with pulmonary arterial hypertension (PAH), an incurable disease characterized by pulmonary arterial (PA) endothelial cell (EC) apoptosis, decreased microvessels and occlusive vascular remod...

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Publicado en:Cell Metab
Main Authors: Diebold, Isabel, Hennigs, Jan K., Miyagawa, Kazuya, Li, Caiyun G., Nickel, Nils P., Kaschwich, Mark, Cao, Aiqin, Wang, Lingli, Reddy, Sushma, Chen, Pin-I, Nakahira, Kiichi, Alcazar, Miguel A. Alejandre, Hopper, Rachel K., Ji, Lijuan, Feldman, Brian J., Rabinovitch, Marlene
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394191/
https://ncbi.nlm.nih.gov/pubmed/25863249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.03.010
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