Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension

Amphetamine (AMPH) or methamphetamine (METH) abuse can cause oxidative damage and is a risk factor for diseases including pulmonary arterial hypertension (PAH). Pulmonary artery endothelial cells (PAECs) from AMPH-associated-PAH patients show DNA damage as judged by γH2AX foci and DNA comet tails. W...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Chen, Pin-I, Cao, Aiqin, Miyagawa, Kazuya, Tojais, Nancy F., Hennigs, Jan K., Li, Caiyun G., Sweeney, Nathaly M., Inglis, Audrey S., Wang, Lingli, Li, Dan, Ye, Matthew, Feldman, Brian J., Rabinovitch, Marlene
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256132/
https://ncbi.nlm.nih.gov/pubmed/28138562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90427
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