BMPR2 Preserves Mitochondrial Function and DNA Integrity During Reoxygenation to Promote Endothelial Survival and Reverse Pulmonary Hypertension

Mitochondrial dysfunction, inflammation and mutant bone morphogenetic protein receptor (BMPR)2 are associated with pulmonary arterial hypertension (PAH), an incurable disease characterized by pulmonary arterial (PA) endothelial cell (EC) apoptosis, decreased microvessels and occlusive vascular remod...

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Bibliographic Details
Published in:Cell Metab
Main Authors: Diebold, Isabel, Hennigs, Jan K., Miyagawa, Kazuya, Li, Caiyun G., Nickel, Nils P., Kaschwich, Mark, Cao, Aiqin, Wang, Lingli, Reddy, Sushma, Chen, Pin-I, Nakahira, Kiichi, Alcazar, Miguel A. Alejandre, Hopper, Rachel K., Ji, Lijuan, Feldman, Brian J., Rabinovitch, Marlene
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394191/
https://ncbi.nlm.nih.gov/pubmed/25863249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.03.010
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